The objective of this study was to prepare and evaluate a novel gelatinized tableting excipient using a mixture of banana starch and Starch 1500. Recently Banana starch has been studied as a direct compression adjuvants for oral tablet dosage forms. Direct compression Paracetamol tablets prepared using Partially pregelatinized banana starch and starch 1500 met the requirements of uniformity of weight, assay, friability, hardness, disintegration time (DT) and in vitro drug release. Novel Pregelatinized banana starch showed adequate binding and disintegrating characteristics. We were made D.C. Paracetamol tablet matrix containing modified banana starch-starch 1500 mixtures and studied their possible erosion-diffusion mechanism and release rate in dissolution tests which was found to be similar to that of the Starch 1500 matrix. In conclusion, the spray-dried granules prepared with Novel banana starch and Starch 1500 showed excellent flow properties and were suitable for tableting.
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